1A61.2/A51.2 Primary syphilis of other sites



Primary syphilis of other sites is caused by the bacterium Treponema pallidum. It is usually transmitted through direct contact with a person who has an active infection. It can also be contracted through sexual contact with someone who is infected.


Diagnosis of primary syphilis of other sites is usually made through a physical examination, laboratory tests, and a detailed medical history. The physical examination may reveal a painless ulcer, or chancre, on the affected area. This ulcer is usually firm and has a clean edge. Laboratory tests such as a blood test or a darkfield microscopy may also be used to confirm the diagnosis.

Differential diagnosis

Primary syphilis of other sites must be distinguished from other sexually transmitted infections such as gonorrhea and chlamydia, as well as other conditions such as herpes and skin cancer.


Primary syphilis of other sites is typically treated with antibiotics such as penicillin, doxycycline, or ceftriaxone. These medications are usually given as a single dose or as a course of treatment.


With prompt and appropriate treatment, primary syphilis of other sites can typically be cured. However, if left untreated, the infection can progress to a more severe form of the disease, known as secondary syphilis. This can cause a range of serious health problems, including blindness, deafness, and even death.

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