Marburg virus disease, also known as Marburg hemorrhagic fever, is caused by a filovirus that is spread through contact with an infected animal or human. It is a rare, severe and highly contagious disease with no known cure.
Diagnosis of Marburg virus disease is based on a combination of clinical, laboratory and epidemiological evidence. Signs and symptoms include fever, headache, muscle aches, abdominal pain, vomiting and diarrhea. Blood tests, imaging and other tests may also be used to diagnose the disease.
Differential diagnosis for Marburg virus disease includes other hemorrhagic fevers such as Ebola, Lassa fever, Kyasanur forest disease, Rift Valley fever and Crimean-Congo hemorrhagic fever.
There is no specific treatment for Marburg virus disease. Treatment is supportive, with the focus on managing symptoms, maintaining fluid and electrolyte balance, and preventing secondary infections.
The prognosis for Marburg virus disease is poor. Most patients die from the virus, and the mortality rate is estimated to be between 25% and 90%.