1F2K/B48.4 Talaromycosis



Talaromycosis is a rare, chronic fungal infection caused by the Talaromyces marneffei fungus. This fungus is found in soil and decaying vegetation in Southeast Asia, particularly in Thailand, Vietnam, and Laos, making it endemic to this region.


Talaromycosis is usually diagnosed through a combination of clinical, laboratory, and imaging tests. Clinical exams can help confirm the presence of fever, skin lesions, and swollen lymph nodes. Laboratory tests such as skin scraping and blood cultures can also be used to identify the presence of the Talaromyces marneffei fungus. Imaging tests such as CT scans and MRI can help detect the presence of any internal organ involvement.

Differential diagnosis

Talaromycosis should be differentiated from other fungal infections such as histoplasmosis, blastomycosis, coccidioidomycosis, and cryptococcosis. It should also be distinguished from other systemic infections such as tuberculosis and HIV.


Talaromycosis is usually treated with antifungal medications. These medications can be taken orally or intravenously. Additionally, patients may be prescribed steroids to reduce inflammation and immunosuppressants to reduce the risk of the infection spreading.


The prognosis for talaromycosis is generally good, as it is a treatable infection. Treatment is typically effective and most patients make a full recovery. However, some patients may experience long-term complications, such as organ damage or chronic fatigue.

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