The exact cause of Chronic Eosinophilic Leukaemia, Not Elsewhere Classified (CEL-NEC) is unknown. It is thought to be a disorder of clonal eosinophil proliferation.
Diagnosis of CEL-NEC is based on the presence of eosinophilia in peripheral blood, bone marrow and tissue biopsy, as well as the absence of signs or symptoms of other diseases that may cause eosinophilia.
Differential diagnosis of CEL-NEC includes other disorders that can cause eosinophilia, such as allergies, parasitic infections, and other hematological disorders.
Treatment of CEL-NEC is mainly supportive and aimed at controlling symptoms. Corticosteroids and other immunosuppressive drugs may be used to reduce eosinophil levels. In some cases, chemotherapy or bone marrow transplantation may be required.
The prognosis of CEL-NEC is generally good, with most patients surviving for several years. However, some patients may experience complications such as organ damage or infections due to the eosinophilia.