2A21.2/C96.2 Mast cell sarcoma



The cause of mast cell sarcoma is not known. However, it is believed that genetic mutations in some patients may predispose them to this type of cancer.


Diagnosis of mast cell sarcoma is based on physical examination, laboratory tests, imaging studies, histologic examination, and flow cytometry.

Differential diagnosis

Differential diagnosis of mast cell sarcoma includes other types of cancer, such as Hodgkin lymphoma and non-Hodgkin lymphoma, and other diseases, such as chronic myelogenous leukemia.


Treatment of mast cell sarcoma typically involves a combination of chemotherapy, radiation therapy, and/or targeted therapy. Surgery may also be used in some cases.


The prognosis for mast cell sarcoma is generally poor, although it can vary depending on the stage of the cancer and the patient’s response to treatment. Patients should discuss their prognosis with their doctor.

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