2A83.0/D47.2 Monoclonal gammopathy of undetermined significance



Monoclonal gammopathy of undetermined significance (MGUS) is a condition characterized by the presence of a paraprotein in the blood. It is caused by an abnormal proliferation of plasma cells in the bone marrow, resulting in an increased level of paraprotein in the serum.


MGUS can be suspected based on the presence of a monoclonal protein in the serum. To confirm the diagnosis, bone marrow biopsy and immunofixation of the serum may be required.

Differential diagnosis

Differential diagnoses for MGUS include multiple myeloma, Waldenström’s macroglobulinemia, lymphoproliferative disorders, and other monoclonal gammopathies.


Since MGUS is considered a pre-malignant condition, treatment is not necessary. However, regular monitoring is recommended to detect any progression to a more serious disease.


The prognosis of MGUS is generally good, with most patients not developing a more serious condition. With regular monitoring, progression can be detected early and prompt action taken to prevent further progression.

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