White matter disorders due to certain systemic diseases are caused by inflammation, infection, or degeneration of the white matter in the brain. These diseases can include multiple sclerosis, HIV, lupus, sarcoidosis, and others.
The diagnosis of white matter disorders due to systemic diseases is based on a combination of the patient’s medical history, physical examination, laboratory tests, imaging studies, and neurological examination.
Differential diagnosis of white matter disorders due to systemic diseases can include a variety of other neurological disorders such as stroke, dementia, and neurodegenerative diseases.
Treatment of white matter disorders due to systemic diseases can include medications, physical therapy, and lifestyle modifications. In some cases, surgery may be necessary.
The prognosis for white matter disorders due to systemic diseases is variable and depends on the specific cause of the disorder and the severity of the symptoms. Generally, patients can expect to have some improvement in their symptoms with treatment.